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elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

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Interestingly, beyond the modulation of p53 and pRb in Caski cells (HPV16 infected) and Hela cells (HPV18 infected), EGCG may target most of the mechanisms involved in cancer transformation and progression, such as cellular proliferation, microtubule stability, angiogenetic processes, and cellular apoptosis