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doi: 10.1016/j.chemosphere.2020.127381 141 LiangY.ZhanJ.LiuD.LuoM.HanJ.LiuX.et al

The Global Burden of Type 2 Diabetes and Obesity Type 2 diabetes (T2D) is characterized by chronically elevated glycemic values due to inadequate synthesis and release of insulin from the pancreatic -cells to meet the demands of the body [1]

Three groups were vaccinated three times at three-week intervals with the following formulations: metE-DNA (100 g/100 L PBS/mouse), MetE protein alone (1 g/100 L PBS/mouse), and 1 g metE protein combined with AddaS03 adjuvant at a 1:1 volume ratio in a total of 100 L PBS/mouse, and AS01 adjuvant (5 g monophosphoryl lipid A [MPL]/5 g QS-21 in a total of 100 L PBS/mouse, representing 1/10th of the human dose of AS01)

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