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Consequently, the transformation of LC3-I to the autophagosome-associated form LC3-II is weakened, thereby reducing Beclin-1 and autophagy-related gene 5 expression and decreasing autophagy vesicle formation [129]

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The released mtDNA can activate cGASSTING signaling, creating a self-reinforcing loop where inflammation further impairs mitochondrial quality control, promotes additional mtDNA release, and accelerates neuronal degeneration

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