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In turn, losing some bacteria can lead to excessive growth of others contributing to dysbacteriosis development (Schroeder, 2019)

A separate study revealed that the 5-HT4R antagonist GR 125487 may exacerbate dopaminergic neuron loss by inhibiting the JAK2/PKA/CREB signaling pathway, altering gut microbiota composition, and increasing reactive glial cells and neuroinflammation in the striatum (Cui et al., 2023)