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T.WangF.YinX.LuY.et al

Primary antioxidants actively inhibit oxidation reactions by scavenging ROS/RNS, while secondary antioxidants act indirectly through chelation of transition metal (iron) ions [83,84] and other specific actions such as anti-inflammatory, induction of protective factors, inhibition of NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase), inhibition of xanthine oxidase, and regulation of redox-sensitive signal transduction pathways, including transcription factors and inhibition of poly (ADP-ribose) 1 (PARP-1) polymerase [81,85,86]

Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes