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Description

O., Mao, R

doi: 10.1515/mr-2021-0014

The following was calculated for [C 25 H 14 Cl 2 N 5 O 4 ] + : 518.0422, found: 518.0397: 1 H NMR (600 MHz, CDCl 3 ) 8.21 (d, J = 8.3 Hz, 1H), 7.95 (d, J = 7.2 Hz, 1H), 7.80 (d, J = 2.5 Hz, 1H), 7.68-7.66 (m, 2H), 7.51 (d, J = 7.3 Hz, 2H), 7.30 (t, J = 7.6 Hz, 2H), 7.21-7.19 (m, 1H), 6.82 (dd, J = 8.1, 6.5 Hz, 1H), 6.75 (t, J = 7.7 Hz, 1H), 6.41 (d, J = 8.2 Hz, 1H)

In 22Rv1 cells, KB-0742 rapidly downregulates nascent transcription, preferentially depleting short half-life transcripts and AR-driven oncogenic programs [1]