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Targeted activator of cell kill (TACK) molecules Antiretroviral therapy (ART) is employed to suppress the replication of HIV-1

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First, the zinc atom located at the centre of the active area, which forms coordination bonds with the prospective inhibitor, is considered the most important binding 27,39

ATP-based luminescence assays, such as the CellTiter-Glo 2.0 Assay, are the preferred platform for HTS drug screening because they offer the highest sensitivity (detecting 15100 cells/well), the simplest protocol (single reagent addition, 10-minute read time), and the lowest coefficient of variation across plate formats