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lonestari to infect mice is attributable to the bactericidal activity of naive mouse serum for this species (Grigery et al., 2005)

Disclosures: Mary Ellen Mackesy-Amiti: Nothing to Disclose, Alexander Gutfraind: Nothing to Disclose, Eric Tatara: Nothing to Disclose, Nicholson Collier: Nothing to Disclose, Scott Cotler: Nothing to Disclose, Kimberly Page: Nothing to Disclose, Jonathan Ozik: Nothing to Disclose, Basmattee Boodram: Nothing to Disclose, Marian Major: Nothing to Disclose, Harel Dahari: Nothing to Disclose 556 BEMNIFOSBUVIR POSES HIGH BARRIER FOR RESISTANCE IN BOTH PRECLINICAL AND PHASE 1B MONOTHERAPY STUDIES Qi Huang 1 Dawei Cai 1 Shannan Lynch 1 Keith Pietropaolo 1 Xiao-Jian Zhou 1 Nancy Agrawal 1 Jean-Pierre Sommadossi 2 , 1 Atea Pharmaceuticals, Inc., 2 Atea Pharmaceuticals, Inc Background: Bemnifosbuvir (BEM), an oral prodrug of a guanosine analog, has potent pan-genotypic, best-in-class in vitro and clinical antiviral activities against all HCV genotypes tested