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For the complex relationship between TMAO and its metabolic precursors and chronic cardiovascular disease, more rigorous experimental protocols need should be designed to eliminate the interference of different precursor metabolites

Trimethylamine-N-oxide (TMAO) Response to Animal Source Foods Varies Among Healthy Young Men and Is Influenced by Their Gut Microbiota Composition: A Randomized Controlled Trial

The function of TMAO in causing endoplasmic reticulum (ER) stress and insulin resistance in diabetes is well-documented, with TMAO levels greater in type 2 diabetics

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