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The activity of NADPH oxidase (Nicotinamide adenine dinucleotide phosphate oxidase, NOX) is upregulated in the aorta, kidney, and adipose tissues in high fat diet-fed rats, leading to excessive production of superoxide ions a major oxygen free radical (129)

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309,422 However, peptide carriers and their cargos often become trapped in acidified endosomes, preventing their entry into the cytoplasm, nucleus, and other subcellular compartments

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