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Cardiomyocytes were plated on cell culture dishes pre-coated with laminin and washed after 2 h to remove dead and non-adherent cells

Simultaneously, in the extracellular pathway, drugs penetrate the nasal epithelium and enter the lamina propria, then move along the perineural spaces surrounding olfactory and trigeminal axons, allowing both small and large molecules to reach the CNS

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Unlike conventional membrane pore formation by aggregated NINJ1 protein that disrupts the membrane, NINJ1 associates with xCT and regulates its level and function