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Advanced imaging techniques combined with biochemical assays for lipid peroxidation products (e.g., specific isoprostanes) and iron speciation in cerebrospinal fluid or blood could enable earlier diagnosis and improved patient stratification

There are no data to guide the management of leg ulcers in PKD, so ulcers are managed similarly to those seen in sickle cell disease or thalassemia

Risk of bias was assessed using Cochrane Collaboration criteria specifically evaluating sequence generation of allocation

Prospective patients should review current FDA guidance on compounded GLP-1 availability and discuss risks, alternatives, and pharmacy sourcing with a licensed clinician before proceeding with any compounded option