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Finally, to confirm whether metformin also increased GLUT1 expression in the human intestine, human intestinal organoids were treated with metformin, and GLUT1 expression was compared

1 There are four well-known SNPs (rs6269, rs4633, rs4818, and rs4680) found in the COMT gene that contribute to low, average, and high pain sensitivity phenotypes

It plays important role in stress-induced apoptosis