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M2-like (or homeostatic) states help preserve neurons by removing extracellular -synuclein fibrils, releasing neurotrophic factors like BDNF (brain-derived neurotrophic factor) and GDNF (glial cell linederived neurotrophic factor), encouraging synaptic repair, boosting glutamate uptake via EAAT2, and creating anti-inflammatory cytokines like IL-10 and TGF-

The roles of matrix metalloproteinases and their inhibitors in human diseases