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Caffeine can also inhibit phosphodiesterase and suppresses the negative effects of adenosine on noradrenaline release, thus can induce fat oxidation (Reference Dulloo, Seydoux and Girardier7)

19 Phosphorylated Met (pMet) directly recruits adapter proteins such as Gab1, Grb2, and Src, which transmit the signal to two major downstream pathways of Akt and ERK (extracellular-regulated kinase)