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the therapeutic agents may be formulated and/or administered with additional active agents such as one or more cytotoxic agents

Ferroptosis is a form of iron-regulated cell death, which is distinguished from other traditional cell death programs by its morphological (shrunken mitochondria with increased membrane density), biochemical (accumulation of free iron and toxic lipid peroxidation, depletion of intracellular antioxidants), and genetic (involvement of many specific genes) features [19]

Here we analyzed serum samples from normal subjects and hyperlipidemia patients and observed an enhanced S -thiolation of HSA in the hyperlipidemia patients as compared to the control individuals