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Numerous data indicate the importance of GSH and the GSH/GSSG ratio in the regulation of tumor cell viability, in the initiation of tumor development, progression, and drug resistance

Ethics declarations Guarantor The scientific guarantor of this publication is Ji Hee Kang

We believe transitioning the manufacturer from the severe supply chain disruption reduction or the likely to be in shortage reduction to the shortage reduction, by beginning the shortage reduction clock as set forth in 428.301(b)(2)(i)(A) or (b)(2)(ii)(A) after the severe supply chain disruption reduction or likely to be in shortage reduction no longer applies, and gradually declining the rebate reduction over time could help prevent exacerbation of the shortage

Calculation of Prepaid Shared Savings As noted in section III.G.5.a of this final rule, we have determined that prepaid shared savings would not result in additional program expenditures