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It is possible to mimic pathological and clinical characteristics of PD in animal models by inhibiting the complex I activity in the electron transport chain using MPTP

Markovic, I., Clouse, K

Current studies demonstrate that LPS exerts multidimensional pathological effects on the heart, including calcium dysregulation, neurohumoral imbalance, oxidative stress, autophagy impairment, and cross-activation of signaling pathways