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Additionally, lactate can be converted to pyruvate intra-mitochondrially via mitochondrial lactate dehydrogenase (mLDH), rather than by the cytosolic isoform (cLDH), a reaction that initiates entry into the tricarboxylic acid (TCA) cycle and oxidative phosphorylation

We next visualized the same paired loci in the cnd1-K658E mutant and found that the shortening of the intra-domain probe distances observed in wild-type cells during mitosis was significantly compromised in the mutant, indicating that domain-based chromosome compaction during mitosis is impaired in the cnd1-K658E mutant (Fig

Metallothionein redox cycle and function