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In addition, future studies could examine the relationship between beta-carotene consumption and other markers of thyroid function beyond just thyroid hormone levels, such as TSH or thyroid antibodies

& Miyazawa, T

Then, they conducted an untargeted metabolite profiling using serum and retinal from newborn mouse pups exposed to phosphate-buffered saline or roxadustat, and pointed out that HIF stabilization by roxadustat acivates serine and 1-carbon metabolism (1CM)

This suggests that the co-treatment with ferrous iron again switched the signaling mechanisms and mode of cell death from mitochondrial dysfunction-dependent necrosis after APAP alone to LPO-dominated ferroptosis after APAP + Fe 2+ (Figure 1)