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Discussion Gout is a prevalent disease resulting from the accumulation of MSU crystals in joints or soft tissues, typically presenting as rapid-onset acute monoarthritis with symptoms such as intense joint pain, erythema, increased local temperature, swelling, and functional impairment [56]

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While most of your bodys hormones are produced in your brains pituitary gland, melatonin is produced in the pineal gland, which is associated with your sleep-wake cycle