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Ethics declarations Ethics approval All animal procedures were conducted in accordance with the guidelines established by the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Maryland School of Medicine (protocol number 00000006)

Members of the Ras GTPase family exhibit distinct requirements for this lipid modification: H-Ras localizes exclusively to lipid rafts, while K-Ras4B shows plasma membrane preference through its polybasic domain

It must, however, be reinstated that our understanding of the role of glycation in mediating neurodegenerative disorders is still at rudimentary level, and preliminary studies have indicated that although metal ions like zinc and iron inhibit glycation of amyloidogenic proteins ( Escherichia coli and several Salmonella sp