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EFSA J 11:168 Fusunyan RD, Quinn JJ, Ohno Y, Macdermott RP, Sanderson IR (1998) Butyrate enhances interleukin (IL)-8 secretion by intestinal epithelial cells in response to IL-1 and lipopolysaccharide

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For vitamin B12 deficiency , treatment varies according to cause and severity: Dietary deficiency : Oral cyanocobalamin supplementation (50150 micrograms daily between meals) is usually effective Pernicious anaemia or malabsorption : Intramuscular hydroxocobalamin injections are required, typically 1 mg three times weekly for two weeks, then maintenance injections every two to three months lifelong Neurological involvement : More intensive initial treatment with 1 mg hydroxocobalamin on alternate days until no further improvement [2] [18] Follow-up should include symptom review and full blood count monitoring after 1-2 months of treatment