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The AOD 9604 with tirzepatide guide explores this topic in more depth

Chemosphere 294, 133796

The IGF pathway consists of three ligands (IGF-I, IGFII, and insulin), their receptors (IGF-IR, IGF-IIR, and insulin receptor), high-affinity binding proteins (IGF binding protein [IGFBP] 16), and their specific proteases (Le Roith, 2003)