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Characteristic features on MRI are increased intensity on T1-weighted images and iso-hypointense on T2-weighted images depending on the amount of melanin contained in the tumor, as well as hemorrhages [12, 13, 14]

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Any suspicious lesion and/or significant change should be considered for biopsy, preferably by excision with conservative surgical margins (2 mm) providing adequate samples for histopathological evaluation.3,8 Non-surgical alternatives such as topical 5-fluorouracil, systemic isotretinoin, topical tretinoin with or without hydrocortisone, topical imiquimod and laser ablation are not effective or safe for the removal of suspicious lesions and are not recommended.8,52

PT-141's mechanism of central appetite suppression through melanocortin receptor activation represents a complementary approach to incretin-based therapies, providing an alternative pathway for addressing obesity through neurohormonal regulation of energy balance