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Glossary ACSL4 acyl CoA synthase long-chain family member 4 ALI acute lung injury ALOX arachidonic acid lipoxygenase AMPK 5 AMP-activated protein kinase CLP caecal ligation and puncture CPX ciclopirox DFO deferoxamine DFP deferiprone DEX dexmedetomidine DLBCL diffuse large B-cell lymphoma DMF dimethyl fumarate DMT1 divalent metal transporter 1 ETC electron transport chain Fer-1 ferrostatin-1 FTH1 ferritin heavy chain-1 GPX4 glutathione peroxidase 4 GSH glutathione GSSG glutathione oxidized HO-1 haem oxygenase-1 H3K27ac histone H3 lysine 27 acetylation H/R hypoxia/reoxygenation IKE imidazole-ketone-erastin IOI ischaemic organ injury I/R ischaemia/reperfusion IRI ischaemia-reperfusion injury IRP2 iron regulatory proteins 2 L-bupivacaine levobupivacaine Lip-1 liproxstatin-1 LPCAT3 lysophosphatidylcholine acyltransferase 3 LPS lipopolysaccharide MDA malondialdehyde MDM2 murine double minute 2 MIRI myocardial ischaemia reperfusion injury mTOR mammalian target of rapamycin NMDAR excitatory N-methyl-D-aspartate receptors Nrf2 nuclear factor erythroid 2-related factor 2 NSCLC Non-small cell lung cancer POCD postoperative cognitive dysfunction PL-PUFA phospholipid-bound polyunsaturated fatty acids PUFA polyunsaturated fatty acids PPP pentose phosphate pathway ROS reactive oxygen species Sev sevoflurane SLC7A11 solute carrier family 7 members 11 TFR1 transferrin receptor 1 VECs vascular endothelial cells 2,2-BP 2,2-bipyridile References 1 AdedoyinO.BodduR.TraylorA.LeverJ

Mol Ther 24(10):18361847

Of the duplicated daughters, ERO1A is ubiquitously expressed

Specifically, SHMT1 binds to the 5 untranslated region (UTR) of its own mRNA to suppress translation, while also interacting with the 5 UTR of SHMT2 mRNA to reduce transcript stability and protein expression (Fig