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Ageing is the most significant risk factor of PD, with most cases occurring in patients over 60 years old (Lees et al

Introduction The global water cycle faces unprecedented anthropogenic stress, with aquatic ecosystems increasingly serving as the ultimate sinks for a vast array of contaminants originating from the technosphere.14 The relentless expansion of industrialisation and intensive agriculture discharges a complex mixture of chemical stressorsranging from heavy metal cations (e.g., Cd2+, Hg2+, Pb2+) to bioactive micropollutantsposing a profound threat to ecological stability.57 Legacy water treatment infrastructures are fundamentally ill-equipped to eliminate these recalcitrant contaminants, which often persist at trace concentrations (ng L1 to g L1) yet exert potent biological effects

P = 0.048) and GPx1 -T/T genotype is associated with a 1.76-fold increase (95% CI = 1.011 to 3.066

Taken together, these results indicated that in response to LPS stimulation, cytoplasmic GSTP translocated to the nucleus, where it bound to HMGB1