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Furthermore, conditioned medium experiments revealed that irisin markedly decreased the microglia-induced neuronal apoptosis rate and enhanced neuronal cell viability

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The EMT is a therapeutic target for fibrotic diseases ( There is growing evidence that proteases and anti-proteases are involved in IPF pathogenesis (Janssen et al., 2018), and LOX activity is increased in fibrotic lung diseases, such as IPF (Tjin et al., 2017)

They can activate several immune cell types, including T cells, B cells, macrophages, and natural killer cells, activate complement, and promote the production of cytokines, thereby regulating many components of the immune system