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Metabolic research focus: Examined in obese rodent studies for changes in weight gain patterns, fat oxidation, and markers associated with lipolysis and lipogenesis

[11] Apart from drug-drug interactions, anabolic steroids may affect laboratory tests: testosterone therapy can decrease levels of thyroxine-binding globulin, resulting in lower total T (thyroxine) readings and higher T uptake, although free thyroid hormone levels remain unchanged and clinical hypothyroidism does not occur

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The recommendation for breaks is therefore precautionary and anecdotal rather than evidence-based