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This disruption allows potentially harmful substances, such as neurotoxic molecules and inflammatory mediators, to pass through the barrier and enter the brain [54,63]

(1) When there are multiple NDCs in a grouped billing and payment code and the manufacturer-reported ASP units for all NDCs are either missing, negative, or equal to zero but there is a positive rebate amount calculated under 427.302(a), CMS will: (i) With respect to NDCs that were sold or marketed during the applicable calendar quarter and for which all NDCs assigned to the grouped billing and payment code lack manufacturer-reported ASP data for the applicable calendar quarter, equally apportion a positive rebate amount to NDCs with missing ASP units that were sold or marketed during the applicable calendar quarter by dividing the total rebate amount for the grouped billing and payment code by the total number of NDCs sold or marketed during the applicable calendar quarter within the billing and payment code

A formulation consisting of 0.2% methylcellulose in a 1% SA gel demonstrated a two- to three-fold increase in dexamethasone release compared to its aqueous solution