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72 HasegawaS.GotoS.TsujiH.OkunoT.AsaharaT.NomotoK.et al (2015)

hydroxide ion (OH ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical ( OH), and superoxide (O 2 ))mediated apoptosis via the Fenton reaction and the HaberWeiss reaction, utilizing the labile iron pool (LIP) as a co-factor [21]

This displays one of the major drawbacks of these synthetic drugs

However, curcumin may increase the risk of bleeding in people taking warfarin and antiplatelet drugs, and can potentiate the effect of other medications such as antibiotics, anti-inflammatories, and chemotherapy agents, therefore some caution is warranted when used in combination with these medications [3, 198]