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HBx induces the degradation of the host Smc5/6 complex, which otherwise would transcriptionally silence cccDNA, but is absent from the mature virion and must be expressed de novo in freshly infected hepatocytes

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NAD + modulates RNA processing Decorating of RNA as a nucleotide analog Chemical modifications of the RNA 5-end play a pivotal role in various biological functions including the protection of RNA from exonuclease cleavage, the recruitment of proteins for pre-mRNA processing and nuclear export and the initiation of protein synthesis