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Coates CJ, Decker H

Repeated injections can lead to the thinning of cartilage and the weakening of tendons, eventually making a rupture more likely

Melatonin stimulates cell apoptosis via the regulation of many apoptosis facilitators, including mitochondria, cytochrome c, Bcl-2, production of reactive oxygen species, and apoptosis receptors

An in vivo study has shown that daily injection of high-dose ascorbate (4 g/kg) in a leukemic mouse model, promoted DNA demethylation and the expression of genes critical for myeloid cell differentiation, and subsequently recapitulated the TET2 restoration phenotypes (105)