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Notably, more than 95% of Kupffer cells expressed TIM4, a marker of embryonically-derived Kupffer cells 25 , indicating that repopulation by monocyte-derived macrophages (which are typically TIM4 ) was minimal under these conditions (Supplementary Fig

The technique of isobaric tags for relative and absolute quantification (iTRAQ) allows unambiguous identification and quantification of proteins expressed in a complex tissue matrix and presents here a snapshot of the hepatoproteome at each of the time-points examined

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