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Kekic offers a framing for this from her clinical practice

The interaction between Keap1 and TRX may influence this process by altering TRXs availability and redox state

603 Meanwhile, EGCG downregulates dual oxidase and NOX expression while increasing SOD and GPX4 activities to reduce lipid peroxidation, suggesting that EGCG plays a neuroprotective role mainly by restoring iron homeostasis and redox balance in PD Drosophila