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Some patients with G6PD deficiency can have haemolysis with exposure to normally tolerable chemicals such as those found in the plant-derived dye henna 129 , probably due to oxidant chemicals interacting with RBCs in skin capillaries

Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123

But it turned out to be a very workable program and, over time, became normal like everything else