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(PubMed) Williams AL, Girard C, Jui D, Sabina A, Katz DL

Add to this the fact the procedure is often traumatic, I dont really like the results on most patients

As the most effective inducer of complement dependent cytotoxicity (CDC), Daratumumab is currently believed as one of the most important mechanisms of MM cell killing in the clinic, efficiently inducing high levels of CDC at a low concentration in bone marrow microenvironment [58, 59]

The evidence is clear: NNMT activity, NAD+ synthesis, and sirtuin responsiveness are all circadian-regulated, and administering the compound outside the optimal metabolic window cuts efficacy by 3050%