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Building on these mechanistic foundations, we explore how ferroptosis intersects with hallmark pathologies in Alzheimers disease (AD) and Parkinsons disease (PD) and examine how iron accumulation in vulnerable brain regions may fuel disease-specific protein aggregation and neurodegeneration

The traditional and definitive treatment for CMS is descent to lower altitudes or sea level

Since neurotransmitters play a crucial role in brain activity, sleep, and wakefulness (170), neuropsychiatric disorders associated with HAT were suggested to be the result of monoaminergic alterations in the brain (171, 172)

doi: 10.7554/eLife.27713 55 TimmermanLAHoltonTYunevaMLouieRJPadroMDaemenAet al