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The diabetes-induced rats had biochemical properties that indicated they had high levels of lipid peroxidation (destructive oxidative stress markers) and low concentrations of glutathione (an antioxidant)

For example, while circulating thyroid hormone has been shown to increase longitudinal bone growth indirectly by increasing systemic GH secretion [83], it also has been shown to directly interact with the epiphyseal chondrocytes and initiate terminal differentiation [87,88]