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Current Opinion in Allergy and Clinical Immunology

Genome instability: classification and mechanisms Genome instability can be broadly classified into three major categories: nucleotide instability (NIN), chromosomal instability (CIN), and microsatellite instability (MSI) [22]

Experiment on mouse has demonstrated that PGC-1 ( PPARGC1B ) binds NRF1 and co-activates genes regulated by NRF1 ( NRF1 and PPARGC1B may be associated with this disease