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The effect was attributed to microbial metabolites that promoted a more youthful systemic environment (for example, boosting the production of certain short-chain fatty acids and reducing pro-inflammatory cytokines) [121]

Rodkey was appointed medical director to establish and develop a new pediatric emergency department at the Cleveland Clinic, and served for 10 years

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S-acetylglutathione has also been shown to decrease TNF-alpha, NF-kappa beta, and F-2 isoprostane.[4,9-12] Additionally, there is mounting evidence that intracellular glutathione levels in antigen-presenting cells (e.g macrophages) may influence the Th1/Th2 cytokine response pattern and promote a balanced immune reaction.*[10]