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This can trigger mitochondrial dysfunction and the production of additional ROS.Mitochondrial Activity: Neurons are highly dependent on mitochondria for energy production, and mitochondrial respiration is a significant source of ROS

Silanikove N, Merin U, Leitner G

Even under conditions of GSHdepletion, which one might expect to exacerbate ER stress, there was no measurable increase in UPR activity

[The Working Group noted that the study was subject to several potential biases, including selection bias (only 23% of the eligible cases participated), unclear exposure assessment, and a very small number of cases ( n = 54), and was therefore considered to be uninformative (results were null).] [The main development in the design of the studies was the evolution from casecontrol studies to cohort studies