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People who are pregnant or breastfeeding, who have active cancer, or who have certain medical conditions should generally avoid it unless a qualified clinician advises otherwise

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Good hygiene and basic precautions help minimize risk: Personal Hygiene Wear gloves and avoid direct contact with GAC media and spent filter material Wash hands thoroughly after handling filter media or performing maintenance Use face masks or respirators in enclosed spaces Equipment Safety Disinfect tools and equipment after use Use appropriate containers for biological materials Follow proper disposal procedures for spent media Treat spent GAC and BAC filter media as potentially biohazardoushandle and dispose of them accordingly

In some circumstances, yes, and the 2026 guideline explicitly moves in that direction for familial hypercholesterolaemia, markedly raised LDL-C, or strong family history