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Neurologic worsening has been linked with toxic levels of free copper in the serum of neurologically presenting patients

In addition, derivatization and conjugation strategies (such as cyclodextrins and trehalose) have been employed to enhance the stability of carnosine against carnosinase-mediated degradation as well as its pharmacological activity (30)

Ethics approval All animal studies were approved by the Institutional Animal Care and Use Committee of Augusta University (Animal Use Protocol #20170868) and were conducted in accordance with the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals