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Supplementing with vitamin B12 lowers homocysteine levels and may improve mood, particularly in response to stress

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There was no change in heart rate in placebo-treated patients

It demonstrates potent anti-glioblastoma activity by: (1) blocking tumor invasion and cytokinesis (inducing polyploidy), (2) disrupting mitochondrial dynamics to elevate ROS and trigger ferroptosis, and (3) sensitizing tumors to radiotherapy/kinase inhibitors via ROS-driven PDGFR/mTOR pathway activation