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There are many unknowns, including dose-response in humans, interactions with other fertility treatments, and differences at various stages of conception including gametogenesis, implantation, and gestation

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Fc-mediated activation of local and circulating innate immune cells such as monocytes, macrophages, neutrophils, dendritic cells and natural killer cells can lead to dysregulated immune activation despite their potential effectiveness at clearing virus-infected cells and debris

However, our study also raises concerns that WD may still be unrecognized in a substantial proportion of affected individuals