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doi:10.1602/neurorx.2.1.3 9

In contrast, in many diseases characterized by a disturbed metabolism, such as obesity, macrophages polarize into M1 macrophages, which leads to inflammation ( Kidney inflammation in earlier stages could be considered a protective response to kidney injury to allow repair of kidney tissue ( CKD is characterized by increased oxidative stress ( Type 2 diabetes is considered a disease with dual etiology, namely metabolic and inflammatory ( Inflammation in hypertension is mediated by macrophages via activation of the renin-angiotensin system (RAS) ( It is known that atherosclerosis is also characterized by chronic inflammation resulting from an imbalance in lipid metabolism in combination with a maladaptive immune response

Subsequent work by Heffernan and coworkers (2001) confirmed the peptides effects in obese mouse models, with chronic administration associated with reduced body weight gain and decreased adiposity without concurrent changes in food intake

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