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Contrasting with these growth-inhibitory actions of IGFBPs, there is also clear evidence of growth promotion by IGFBPs in both cancer and non-cancer cells, as well as extensive clinical data linking high IGFBP expression in a variety of cancers to a more aggressive phenotype and poor patient survival [17]

291 : 861867 Neuwelt EA, Pagel MA, Hasler BP, Deloughery TG and Muldoon LL (2001) Therapeutic efficacy of aortic administration of N -acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model