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Various studies have evaluated clinical factors, biomarkers, radiological and physiological parameters (respiratory function tests and exercise capacity) and presence of comorbidities, associated with a higher risk of mortality, both at the time of follow-up and developmentally during follow-up.28 Factors associated with poor evolution are (Table 4): - Aged over 70 years.28 - Associated comorbidities: pulmonary hypertension, emphysema and bronchogenic carcinoma

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Both processes are considered crucial for maintaining the overall functionality of the cells

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