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Furthermore, in the bloodstream, it is immediately metabolized in part by the action of glycoprotein-P, a transmembrane protein that depends on adenosine triphosphate (ATP) and leads to the efflux of curcumin, as well as by enzymes of first-pass metabolism in the liver and small intestine, which reduce it to its metabolites di-, tetra-, hexa-, and octa-hydrocurcumin (Fig

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